, On a normal person, AC-11 was administered for 8 months.
, Before and after administration, blood samples were gathered and the DNA damage tests caused by oxidation stress(H2O2) were performed for each blood sample.
, The DNA damages of white blood cells after oxidation stress and after a certain period of cultivation(repair) were measured.
, 『 The DNA link amputation damage was evaluated through the alkaline elution method.
, Result : The group that had ingested AC-11, when compared to the control group, had significantly high DNA repair ability. We can expect the acceleration effect on repair of damaged DNA from the ingestion of AC-11.
  , AC-11 was administered to rats for 8 weeks
, Rats were exposed to radiation, after 3 hours of which the spleen cells were extracted for the evaluation of DNA damage.
, 『 The DNA link amputation damage was evaluated through the alkaline elution method.
Result : After the ingestion by rats, DNA repair function has shown to be accelerating.
, Upon the ingestion by rats, the DNA repair functions within the body have shown to be accelerating. Due to the ingestion of AC-11, we can expect the improvement of DNA repair within the living body.
  , We have prepared UV protectant cream(SPF15) containing AC-11 and UV protectant cream(SPF15) that does not contain AC-11. 42 volunteers applied the cream and were exposed to sunlight for given periods of time. Then, the application area of UV protectant cream with and without AC-11 were carefully observed.
Result : Formation of red specks and the formation of blisters have been meaningfully improved. (p<0.0001). After the application of AC-11, we can expect the protective effects of skin irritations from suntans.
  , The effects of AC-11 in cell multiplication and activation of NFリB on tumor cells of human beings and mice.
 

, The propagation of lymphoma cells and the activity of NFリB were suppressed by AC-11. NFリB is a molecule related to the cell division and other various DNA manifestation.

, AC-11 can be considered to control the activation of NFリB, and to affect the control system of cell multiplication.

 

Noah Scheinfeld, MD JD1, Gerald Wachs, MD RPH2
St Luke¨s-Roosevelt Hospital Center, New York City, NY; 2Saint Barnabas Health Care System, New Jersey

AC-11 Back Ground & Studies Objective
, AC-11 is an aqueous extract of C-Med-100∝
, AC-11 can be administered orally or applied topically
, AC-11 in vitro & in vivo YDNA repair & DNA damage
, AC-11 reduces erythema, blistering & pain post UV tx
, Topical AC-11 enhancement of DNA integrity in humans was assessed in 3 studies

Rationale For AC-11 Studies
, DNA is a chromophore for UV 280-340 nm1
, Epidermal dimer formation and erythema appear to be interrelated phenomena2,3
, AC-11 enhances the repair, but not the formation, of cyclobutyl pyrimidine dimers (TT-dimers) in human living skin equivalents4

AC-11 Decreased Oxidative DNA Damage in Humans5
, Population: 5 healthy volunteers; 35 - 55 yrs old
, AC-11: 350 mg/day po for 4 weeks
, Outcome Measure: 8-hydroxyguanine

AC-11 Enhanced DNA Repair in Human Monocytes (wbc)6
, Population: 12 healthy volunteers (8 treated with AC-11)
, AC-11: 250 or 350 mg/day for 6 weeks
, Outcome Measure: Single strand breaks in wbc DNA after H2O2 exposure pre & post AC-11

AC-11 Decreased Oxidative DNA Damage in Humans7
, Population: 14 volunteers-9 with chronic dzs
, AC-11: 400 mg/day po for 4 weeks
, Outcome Measure: 8-hydroxyguanine
, 9 of 14 volunteers (64%) had decreased 8-hydroxyguanine DNA adducts
, Only 1 had elevated 8-hydroxyguanine DNA adducts at baseline (22/109 bases); it was reduced to 2/109 bases after AC-11 therapy